Molecular analysis of Iranian families with sickle cell disease.

@article{Ayatollahi2005MolecularAO,
  title={Molecular analysis of Iranian families with sickle cell disease.},
  author={Maryam Ayatollahi and Maryam Zakerinia and Mansour Haghshenas},
  journal={Journal of tropical pediatrics},
  year={2005},
  volume={51 3},
  pages={136-40}
}
Sickle hemoglobin is a mutant hemoglobin in which valine has been substituted for the glutamic acid normally at the sixth amino acid of the beta-globin chain. Detection of the single base pair mutation at codon 6 of the beta-globin gene is important for the prenatal diagnosis of sickle cell anemia and sickle cell disease. Application of the polymerase chain reaction technology to detect sickle cell patients and heterozygous carriers in a group of patients suspected for sickle cell disease was… CONTINUE READING

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