Molecular analysis of HER2 signaling in human breast cancer by functional protein pathway activation mapping.


PURPOSE Targeting of the HER2 protein in human breast cancer represents a major advance in oncology but relies on measurements of total HER2 protein and not HER2 signaling network activation. We used reverse-phase protein microarrays (RPMA) to measure total and phosphorylated HER2 in the context of HER family signaling to understand correlations between… (More)
DOI: 10.1158/1078-0432.CCR-12-0452


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