Molecular analysis and breakpoint definition of a set of human chromosome 21 somatic cell hybrids.

@article{Graw1995MolecularAA,
  title={Molecular analysis and breakpoint definition of a set of human chromosome 21 somatic cell hybrids.},
  author={Sharon L. Graw and Katheleen Gardiner and K Hall-Johnson and Ibitoruh Hart and Anthony Joetham and Katherine Walton and Deborah D. Donaldson and David Patterson},
  journal={Somatic cell and molecular genetics},
  year={1995},
  volume={21 6},
  pages={415-28}
}
Rodent-human somatic cell hybrids containing single human chromosomes or chromosome fragments are extremely valuable in physical mapping, marker analysis, and disease mapping. Chromosome 21 has been extensively studied in this fashion, and a single set of hybrids has been utilized in mapping the majority of chromosome 21 markers. The utility of a set of hybrids depends upon the definition of the human chromosome content. Recently, Chumakov and coworkers (1) utilized 198 chromosome 21 markers in… CONTINUE READING