Molecular analyses of juvenile granulosa cell tumors bearing AKT1 mutations provide insights into tumor biology and therapeutic leads.

@article{Auguste2015MolecularAO,
  title={Molecular analyses of juvenile granulosa cell tumors bearing AKT1 mutations provide insights into tumor biology and therapeutic leads.},
  author={Aur{\'e}lie Auguste and Laurianne Bessi{\`e}re and Anne-Laure Todeschini and Sandrine Caburet and S. Sarnacki and Jaime Prat and Emanuela D'angelo and Pierre de la Grange and Olivier Ariste and Fr{\'e}d{\'e}ric Lemoine and B{\'e}rang{\`e}re Legois and Charles S Sultan and Alain Zider and Louise Galmiche and Nicolas Kalfa and Reiner A. Veitia},
  journal={Human molecular genetics},
  year={2015},
  volume={24 23},
  pages={6687-98}
}
Juvenile granulosa cell tumors (JGCTs) of the ovary are pediatric neoplasms representing 5% of all granulosa cell tumors (GCTs). Most GCTs are of adult type (AGCTs) and bear a mutation in the FOXL2 gene. The molecular basis of JGCTs is poorly understood, although mutations in the GNAS gene have been reported. We have detected in-frame duplications within the oncogene AKT1 in >60% of the JGCTs studied. Here, to evaluate the functional impact of these duplications and the existence of potential… CONTINUE READING