Molecular analyses of chromosome 12 in chronic lymphocytic leukemia.

@article{Einhorn1989MolecularAO,
  title={Molecular analyses of chromosome 12 in chronic lymphocytic leukemia.},
  author={Stefan Einhorn and Karin M. Burvall and Gunnar Juliusson and G{\"o}sta Gahrton and T Meeker},
  journal={Leukemia},
  year={1989},
  volume={3 12},
  pages={871-4}
}
Trisomy 12 is the most common chromosomal aberration in chronic B lymphocytic leukemia (B-CLL). In this study we have investigated trisomy 12 and posed two major questions: (a) What is the origin of the third copy of chromosome 12? and (b) What is the proportion of trisomy 12 cells in malignant clones with this aberration? The origin of an extra copy of… CONTINUE READING