Molecular analyses of cell origin and detection of circulating tumor cells in the peripheral blood in alveolar soft part sarcoma.

@article{Hoshino2009MolecularAO,
  title={Molecular analyses of cell origin and detection of circulating tumor cells in the peripheral blood in alveolar soft part sarcoma.},
  author={Makiko Hoshino and Akira Ogose and Hiroyuki Kawashima and Tomohiro Izumi and Tetsuo Hotta and Kazuhiko Hatano and Tetsuro Morita and Hiroshi Otsuka and Hajime Umezu and Shunsuke Yanoma and Mamoru Tsukuda and Naoto Endo},
  journal={Cancer genetics and cytogenetics},
  year={2009},
  volume={190 2},
  pages={
          75-80
        }
}
Alveolar soft part sarcoma (ASPS) is a distinct, rare soft tissue tumor with an unknown histogenesis and a tendency for late widespread metastases to lung, bone, and brain. It is now clear that they are caused by a specific unbalanced translocation, der(17)t(X;17)(p11;q25), which results in the formation of an ASPSCR1-TFE3 (alias ASPL-TFE3) fusion gene. The rearrangement results in the expression of chimeric transcripts, which can be identified by means of reverse transcriptase-polymerase chain… CONTINUE READING
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