Molecular alterations of p73 in human esophageal squamous cell carcinomas: loss of heterozygosity occurs frequently; loss of imprinting and elevation of p73 expression may be related to defective p53.

@article{Cai2000MolecularAO,
  title={Molecular alterations of p73 in human esophageal squamous cell carcinomas: loss of heterozygosity occurs frequently; loss of imprinting and elevation of p73 expression may be related to defective p53.},
  author={Yuyang Christine Cai and Guo Yi Yang and Yan Nie and Li Wang and Xintai Zhao and Y L Song and Darren N. Seril and Jie Liao and Eric Poe Xing and Chung S Yang},
  journal={Carcinogenesis},
  year={2000},
  volume={21 4},
  pages={683-9}
}
p73 is structurally and functionally related to p53 and is possibly a tumor suppressor gene. Using 15 surgically resected frozen esophageal specimens containing both squamous cell carcinomas (ESCC) and neighboring normal epithelia, we studied p73 gene alterations and mRNA expression. Loss of heterozygosity of the p73 loci was found in nine of 14 informative cases (64%). A polymorphism at codon 173 (Thr) of p73 was identified (eight samples had ACC and seven had ACT), but mutation was not… CONTINUE READING

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