Molecular alterations of cells resistant to platinum drugs: role of PKCalpha.

@article{Righetti2006MolecularAO,
  title={Molecular alterations of cells resistant to platinum drugs: role of PKCalpha.},
  author={Sabina Carla Righetti and Paola Perego and Nives Carenini and Elisabetta Corna and Laura Dal Bo and Sabrina Cedrola and Caterina A M La Porta and Franco Zunino},
  journal={Biochimica et biophysica acta},
  year={2006},
  volume={1763 1},
  pages={93-100}
}
Development of resistance to platinum compounds may involve not only overexpression of defence mechanisms but also alterations in cellular response to the drug-induced genotoxic stress. To investigate the cellular bases of response to platinum compounds, we examined the profile of gene expression of ovarian carcinoma cells exhibiting sensitivity (A2780) or resistance (A2780/BBR3464) to platinum compounds. Using display PCR, we found that acquisition of resistance to the multinuclear platinum… CONTINUE READING

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