Molecular alterations in the carcinogenesis and progression of hepatocellular carcinoma: Tumor factors and background liver factors.

@article{Inokawa2016MolecularAI,
  title={Molecular alterations in the carcinogenesis and progression of hepatocellular carcinoma: Tumor factors and background liver factors.},
  author={Yoshikuni Inokawa and Kenichi Inaoka and Fuminori Sonohara and Masamichi Hayashi and Mitsuro Kanda and Shuji Nomoto},
  journal={Oncology letters},
  year={2016},
  volume={12 5},
  pages={3662-3668}
}
Although hepatocellular carcinoma (HCC) is associated with poor prognosis worldwide, the molecular mechanisms underlying the carcinogenesis and progression of this disease remain unclear. Several tumor characteristics have previously been demonstrated to be prognostic factors of survival following hepatic resection, or the recurrence of HCC or other types of cancer. Comparisons of normal tissues and HCC tumor tissues have revealed the presence of numerous molecular alterations in HCC, including… CONTINUE READING