Molecular alterations in spontaneous sputum of cancer-free heavy smokers: results from a large screening program.

@article{Baryshnikova2008MolecularAI,
  title={Molecular alterations in spontaneous sputum of cancer-free heavy smokers: results from a large screening program.},
  author={Ekaterina Baryshnikova and Annarita Destro and Maurizio Valentino Infante and Silvio Cavuto and Umberto Cariboni and Marco Alloisio and Giovanni Luca Ceresoli and Romano Fabio Lutman and Giorgio Brambilla and Giuseppe Chiesa and Gianni Ravasi and Massimo G Roncalli},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2008},
  volume={14 6},
  pages={1913-9}
}
PURPOSE The high mortality rate for lung cancer is likely to be reduced by the development of a panel of sensitive biological markers able to identify early-stage lung cancers or subjects at high risk. The aim of this study was to establish the frequency of K-ras and p53 mutations and p16(INK4A), RASSF1A, and NORE1A hypermethylation in sputum of a large cohort of cancer-free heavy smokers and to assess whether these markers are suitable for a routine use in the clinical practice for the early… CONTINUE READING
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