Molecular alterations in hepatocyte transport mechanisms in acquired cholestatic liver disorders.

@article{Lee2000MolecularAI,
  title={Molecular alterations in hepatocyte transport mechanisms in acquired cholestatic liver disorders.},
  author={J M Lee and James Boyer},
  journal={Seminars in liver disease},
  year={2000},
  volume={20 3},
  pages={373-84}
}
Recent advances in the molecular cloning of membrane transport systems that determine bile formation have facilitated studies of the molecular mechanisms of cholestatic liver disease. The present review summarizes what has been learned about the molecular alterations of these membrane transporters in hepatocytes and cholangiocytes in acquired cholestatic liver disorders. Much of this information has been obtained from the study of animal models of cholestasis and from more limited studies in… CONTINUE READING

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