Molecular alterations in exocrine neoplasms of the pancreas.

  title={Molecular alterations in exocrine neoplasms of the pancreas.},
  author={Prathibha Ranganathan and Hindahally Chandregowda Harsha and Akhilesh Pandey},
  journal={Archives of pathology & laboratory medicine},
  volume={133 3},
CONTEXT Pancreatic cancer is one of the leading causes of cancer-related deaths. Most cases are diagnosed at an advanced stage when the disease is beyond surgical intervention. Molecular studies during the past decade have contributed greatly to our understanding of this disease. Various germ-line and somatic mutations associated with pancreatic cancers have been characterized, along with abnormal variations in the gene expression patterns. A thorough characterization of molecular alterations… CONTINUE READING