Molecular alterations in a patient with Turcot's syndrome.


Cells of a patient with Turcot's syndrome and of her parents were evaluated for the presence of molecular alterations in the p53 and the Ki-ras gene. Deletions on chromosome 17p, overexpression and point mutations of the p53 gene as well as mutations of the Ki-ras gene were detected in primary and metastatic tumour but not in the germline of the patient nor in her parents.

DOI: 10.1038/bjc.1993.379

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@article{Rochlitz1993MolecularAI, title={Molecular alterations in a patient with Turcot's syndrome.}, author={C. F. Rochlitz and Immo Heide and E. de Kant and Andreas Neubauer and Christian A. Schmidt and Petra Neuhaus and Dieter Huhn and Richard P Herrmann}, journal={British Journal of Cancer}, year={1993}, volume={68}, pages={519 - 523} }