Molecular alterations and tumor suppressive function of the DUSP22 (Dual Specificity Phosphatase 22) gene in peripheral T-cell lymphoma subtypes

@inproceedings{Mlard2016MolecularAA,
  title={Molecular alterations and tumor suppressive function of the DUSP22 (Dual Specificity Phosphatase 22) gene in peripheral T-cell lymphoma subtypes},
  author={Pierre M{\'e}lard and Yamina Idrissi and Laetitia Andrique and Sandrine Poglio and Martina Prochazkova-Carlotti and Sabine Berhouet and C{\'e}cile Boucher and Elodie Laharanne and Edith Chevret and A Pham-Ledard and Andr{\'e}a Carla de Souza G{\'o}es and V{\'e}ronique Guyonnet-Dup{\'e}rat and Alice Bibeyran and François Moreau-Gaudry and B{\'e}atrice Vergier and Marie Beylot-Barry and Jean-Philippe Merlio and David Cappellen},
  booktitle={Oncotarget},
  year={2016}
}
Monoallelic 6p25.3 rearrangements associated with DUSP22 (Dual Specificity Phosphatase 22) gene silencing have been reported in CD30+ peripheral T-cell lymphomas (PTCL), mostly with anaplastic morphology and of cutaneous origin. However, the mechanism of second allele silencing and the putative tumor suppressor function of DUSP22 have not been investigated so far. Here, we show that the presence, in most individuals, of an inactive paralog hampers genetic and epigenetic evaluation of the DUSP22… CONTINUE READING