Molecular aging of the brain, neuroplasticity, and vulnerability to depression and other brain-related disorders

@inproceedings{Sibille2013MolecularAO,
  title={Molecular aging of the brain, neuroplasticity, and vulnerability to depression and other brain-related disorders},
  author={Etienne Sibille},
  booktitle={Dialogues in clinical neuroscience},
  year={2013}
}
The increased risk for neurodegenerative and neuropsychiatric disorders associated with extended lifespan has long suggested mechanistic links between chronological age and brain-related disorders, including depression, Recent characterizations of age-dependent gene expression changes now show that aging of the human brain engages a specific set of biological pathways along a continuous lifelong trajectory, and that the same genes that are associated with normal brain aging are also frequently… CONTINUE READING
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