Molecular adsorbent recirculating system dialysis in patients with acute liver failure who are assessed for liver transplantation

@article{Camus2006MolecularAR,
  title={Molecular adsorbent recirculating system dialysis in patients with acute liver failure who are assessed for liver transplantation},
  author={Christophe Camus and Sylvain Lavou{\'e} and Arnaud Gacouin and Yves le Tulzo and Richard Lorho and Karim Boudjema and Christian Jacquelinet and R{\'e}mi Thomas},
  journal={Intensive Care Medicine},
  year={2006},
  volume={32},
  pages={1817-1825}
}
ObjectiveTo assess the usefulness of dialysis with the molecular adsorbent recirculating system (MARS) in patients with acute liver failure who fulfil criteria for liver transplantation.DesignObservational cohort study.SettingICU at a liver transplantation centre.PatientsTwenty-two patients (23 episodes) received MARS dialysis. They were either listed for LT (n = 14), delayed (n = 1), or not listed (contra-indication, n = 7).InterventionsA total of 56 MARS treatments (median per patient 2; mean… 
Albumin Dialysis in Liver Failure: Comparison of Molecular Adsorbent Recirculating System and Single Pass Albumin Dialysis—A Retrospective Analysis
TLDR
This retrospective analysis suggests equal efficacy of MARS and SPAD; however, prospective assessment to further define the role of SPAD in the treatment of acute or acute‐on‐chronic liver failure is needed.
Molecular adsorbent recirculating system (Mars) in patients with primary nonfunction and other causes of graft dysfunction after liver transplantation in the era of extended criteria donor organs.
TLDR
In all patients, a decrease in serum bilirubin, bile acids, serum creatinine, and ammonia levels was observed after treatment with MARS, and a considerable improvement of HE, as well as renal and synthetic liver functions, was observed in 4 of 5 patients with graft dysfunction, but not among those with primary nonfunction.
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TLDR
MARS treatment appears to be ineffective in AOCLF with end-stage cirrhosis without an LTX option, and the etiology of liver disease was the most important prognostic factor.
Molecular adsorbents recirculating system in patients with severe liver failure. Experience of a single Romanian centre.
TLDR
MARS therapy efficiently removed water soluble and albumin-bound toxins and was well tolerated by the patients and presented spontaneous liver recovery.
Liver Transplantation Avoided in Patients With Fulminant Hepatic Failure Who Received Albumin Dialysis With the Molecular Adsorbent Recirculating System While on the Waiting List: Impact of the Duration of Therapy
  • C. Camus, S. Lavoué, +5 authors Y. le Tulzo
  • Medicine
    Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
  • 2009
TLDR
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The effect of molecular adsorbent recirculating system treatment on survival, native liver recovery, and need for liver transplantation in acute liver failure patients *
TLDR
MARS treatment might partly explain the trend toward increased survival of ALF patients with unknown etiology, and Interpretation of the results was difficult in toxic etiology patients on account of differing baseline statuses.
Albumin dialysis with molecular adsorbent recirculating system (MARS) for the treatment of hepatic encephalopathy in liver failure.
TLDR
The following manuscript reviews the technical features of MARS operation and some of the clinical trials that analyze the efficacy of the system in the therapy of liver diseases.
Molecular adsorbent recirculating system (MARS) in acute liver injury and graft dysfunction: Results from a case-control study
TLDR
Although it did not improve 28-day mortality, MARS therapy improved the short-term response in patients with acute liver injury as well as in those with GD, and resulted in the sustained stabilization of liver function and improved liver regeneration.
Albumin Dialysis MARS: Knowledge from 10 Years of Clinical Investigation
TLDR
Together, albumin dialysis represents a valuable therapeutic tool for the treatment of various types of liver failure and ongoing and future studies will help define the optimal patient selection and technical process parameters such as session length and frequency of treatment.
Bench-to-bedside review: Current evidence for extracorporeal albumin dialysis systems in liver failure
TLDR
Although MARS and Prometheus have shown biochemical improvements in AoCLF and ALF, additional studies are required to show conclusive benefit in short- and long-term survival, and the appropriate comparator is standard medical therapy rather than head-to-head comparisons of different forms of albumin dialysis.
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