Molecular activities of meiosis-specific proteins Hop2, Mnd1, and the Hop2-Mnd1 complex.

@article{Pezza2006MolecularAO,
  title={Molecular activities of meiosis-specific proteins Hop2, Mnd1, and the Hop2-Mnd1 complex.},
  author={Roberto J Pezza and Galina V. Petukhova and Rodolfo Ghirlando and R. Daniel Camerini-Otero},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 27},
  pages={
          18426-34
        }
}
The mouse Hop2 and Mnd1 proteins, which can form a stable heterodimeric complex, ensure the proper synapsis of homologous chromosomes in meiosis by acting in concert with Rad51 and Dmc1 to promote the strand invasion (D-loop formation) step of homologous recombination. Hop2 alone promotes D-loop formation, but Mnd1 and the Hop2-Mnd1 complex do not. Here we show that only the heterodimer complex, but not the individual proteins, can stimulate strand invasion by Dmc1. Furthermore, we demonstrate… CONTINUE READING

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