Molecular activation of PPARgamma by angiotensin II type 1-receptor antagonists.

Abstract

OBJECTIVE AND DESIGN Elevated blood pressure and insulin resistance are strongly associated in patients. We explored the potential for the anti-hypertensive angiotensin II type 1-receptor (ATR(1)) antagonists to improve insulin sensitivity through modulation of the nuclear receptor PPARgamma, in vitro and in vivo compared to the potent insulin sensitizer… (More)

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