Molecular actions of nitric oxide in mesangial cells.

  title={Molecular actions of nitric oxide in mesangial cells.},
  author={Katrin B Sandau and Bernhard Br{\"u}ne},
  journal={Histology and histopathology},
  volume={15 4},
Nitric oxide (NO) is a widely recognized mediator of physiological and pathophysiological signal transmission. Its generation through L-arginine metabolism is relevant in the mesangium of the kidney where NO is produced by constitutive and inducible NO-synthase isoenzymes. Signaling is achieved through target interactions via redox and additive chemistry. In mesangial cells (MC), the outcome of these modifications promote on one side activation of soluble guanylyl cyclase while on the other… CONTINUE READING