Molecular abnormalities in myeloid leukemias and myelodysplastic syndromes.


Analysis of chromosome translocations in human myeloid leukemias and myelodysplastic syndromes has identified a number of genes involved in the pathogenesis of these diseases. Most of the genes identified to date can be grouped into one of three major classes--transcription factors, tyrosine kinases or nuclear pore proteins. Recent insights into the… (More)


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