Molecular ablation of ventricular tachycardia after myocardial infarction

  title={Molecular ablation of ventricular tachycardia after myocardial infarction},
  author={Tetsuo Sasano and Amy D. McDonald and Kan Kikuchi and J Kevin Donahue},
  journal={Nature Medicine},
Ventricular tachycardia is a common and lethal complication after myocardial infarction. Here we show that focal transfer of a gene encoding a dominant-negative version of the KCNH2 potassium channel (KCNH2-G628S) to the infarct scar border eliminated all ventricular arrhythmias in a porcine model. No proarrhythmia or other negative effects were discernable. Our results demonstrate the potential viability of gene therapy for ablation of ventricular arrhythmias. 

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