Molecular Variation at the SLC6A3 Locus Predicts Lifetime Risk of PTSD in the Detroit Neighborhood Health Study

@inproceedings{Chang2012MolecularVA,
  title={Molecular Variation at the SLC6A3 Locus Predicts Lifetime Risk of PTSD in the Detroit Neighborhood Health Study},
  author={Shun-Chiao Chang and Karestan Koenen and Sandro Galea and Allison E Aiello and Richelo Soliven and Derek E. Wildman and Monica Uddin},
  booktitle={PloS one},
  year={2012}
}
Recent work suggests that the 9-repeat (9R) allele located in the 3'UTR VNTR of the SLC6A3 gene increases risk of posttraumatic stress disorder (PTSD). However, no study reporting this association to date has been based on population-based samples. Furthermore, no study of which we are aware has assessed the joint action of genetic and DNA methylation variation at SLC6A3 on risk of PTSD. In this study, we assessed whether molecular variation at SLC6A3 locus influences risk of PTSD. Participants… CONTINUE READING