Molecular Validation of LpxC as an Antibacterial Drug Target in Pseudomonas aeruginosa

@article{Mdluli2006MolecularVO,
  title={Molecular Validation of LpxC as an Antibacterial Drug Target in Pseudomonas aeruginosa},
  author={Khisimuzi E Mdluli and P. Witte and T. Kline and A. Barb and A. Erwin and Bryce E Mansfield and Amanda L. McClerren and M. Pirrung and L. Tumey and P. Warrener and C. Raetz and C. K. Stover},
  journal={Antimicrobial Agents and Chemotherapy},
  year={2006},
  volume={50},
  pages={2178 - 2184}
}
ABSTRACT LpxC [UDP-3-O-(R-3-hydroxymyristoyl)-GlcNAc deacetylase] is a metalloamidase that catalyzes the first committed step in the biosynthesis of the lipid A component of lipopolysaccharide. A previous study (H. R. Onishi, B. A. Pelak, L. S. Gerckens, L. L. Silver, F. M. Kahan, M. H. Chen, A. A. Patchett, S. M. Galloway, S. A. Hyland, M. S. Anderson, and C. R. H. Raetz, Science 274:980-982, 1996) identified a series of synthetic LpxC-inhibitory molecules that were bactericidal for… Expand
61 Citations
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