Molecular Targeting with Recombinant Cytotoxins of Interleukin-13 Receptor α 2-expressing Glioma

@article{Mintz2003MolecularTW,
  title={Molecular Targeting with Recombinant Cytotoxins of Interleukin-13 Receptor α 2-expressing Glioma},
  author={Akiva Mintz and Denise M. Gibo and A B Madhankumar and Waldemar Debinski},
  journal={Journal of Neuro-Oncology},
  year={2003},
  volume={64},
  pages={117-123}
}
A restricted receptor for interleukin 13 (IL-13Rα2) is over-expressed in high-grade astrocytoma (HGA), but not in normal organs. In order to design and examine new anti-HGA therapies, which are molecularly directed against IL-13Rα2, we established an IL-13Rα2-expressing syngeneic immunocompetent murine model of HGA. The model was obtained by transfecting G… CONTINUE READING