Molecular Survey of β-Lactamases Conferring Resistance to Newer β-Lactams in Enterobacteriaceae Isolates from Polish Hospitals

@article{Empel2008MolecularSO,
  title={Molecular Survey of $\beta$-Lactamases Conferring Resistance to Newer $\beta$-Lactams in Enterobacteriaceae Isolates from Polish Hospitals},
  author={Joanna Empel and Anna Baraniak and Elżbieta Literacka and Agnieszka Mr{\'o}wka and Janusz Fiett and Ewa Sadowy and Waleria Hryniewicz and Marek Gniadkowski},
  journal={Antimicrobial Agents and Chemotherapy},
  year={2008},
  volume={52},
  pages={2449 - 2454}
}
ABSTRACT The first national survey of resistance to newer β-lactams in nosocomial populations of Enterobacteriaceae in Poland was performed. The study covered all nonrepetitive enterobacterial isolates cultured from specimens from inpatients in 13 regional secondary-care hospitals from November 2003 to January 2004. Among 2,388 isolates, the predominant species was Escherichia coli (59.6%), followed by Proteus mirabilis (14.5%) and Klebsiella spp. (8.5%). The frequency of extended-spectrum… 
Prevalence of extended-spectrum beta-lactamase-producing Enterobacteriaceae in Bahrain.
TLDR
This is the first report from Bahrain and it indicates that the prevalence of ESBL-producing isolates is high and strict infection control is recommended to prevent trafficking into the community.
Prevalence of Extended Spectrum Beta-Lactamases among Enterobacteriaceae Isolated from Intrahospital Patients in Serbia
TLDR
Findings might help clinicians in deciding the appropriate empirical treatment for intrahospital patients and emphasize the increasing problem of antimicrobial resistance in Serbia.
High prevalence and molecular characterization of extended-spectrum β-lactamase-producing Proteus mirabilis strains in southern Croatia.
The aim of this study was to determine the prevalence and antibiotic resistance rates of extended-spectrum β-lactamase (ESBL)-producing Proteus mirabilis strains isolated from inpatients at the Split
Population Distribution of Beta-Lactamase Conferring Resistance to Third-Generation Cephalosporins in Human Clinical Enterobacteriaceae in The Netherlands
TLDR
It is demonstrated that bla CTX-M-15 is the most prevalent ESBL and a larger than previously reported prevalence of ampC genes among Enterobacteriaceae responsible for resistance to third-generation cephalosporins is reported.
Distribution and antimicrobial susceptibility profile of extended-spectrum β-lactamase-producing Proteus mirabilis strains recently isolated in Japan.
TLDR
Results show that approximately one-half of the P. mirabilis isolates from clinical specimens in Japan are ESBL-producers and that the potential for concomitant fluoroquinolone resistance must also be considered.
Nosocomial infection and characterization of extended-spectrum β-lactamases-producing Enterobacteriaceae in Northeast Brazil.
TLDR
These results support the need for extending ESBL detection methods to different pathogens of the Enterobacteriaceae family because these methods are only currently standardized by the CLSI for Escherichia coli, Klebsiella pneumoniae, KleBSiella oxytoca and Proteus mirabilis.
Strains of Klebsiella pneumoniae producing extended spectrum beta-lactamases, isolated from organ recipients.
TLDR
The ESBL mechanism of resistance is frequent among K pneumoniae strains isolated from transplant recipients, and the genotype of Klebsiella pneumoniae β-lactamase is defined.
Characterization of infections with extended-spectrum β-lactamase producing Escherichia coli and Klebsiella species at a major military medical center.
TLDR
The need for ongoing monitoring of local microbial epidemiologic trends as changes in prescribing practices may become necessary if resistance continues to spread is emphasized.
Survey of metallo-β-lactamase-producing Enterobacteriaceae colonizing patients in European ICUs and rehabilitation units, 2008-11.
TLDR
This study provided fully comparable data on the occurrence and molecular characteristics of VIM-producing Enterobacteriaceae in a group of hospital units across Europe, documenting recent changes in their epidemiology.
The prevalence of ESBL and AmpC β-lactamases in uropathogenic isolates of Escherichia coli in a tertiary care hospital in Southwest Iran
TLDR
The findings revealed that the prevalence of AmpC β-lactamases is rising in Iran, leading to failure in treatment, and accurate and precise methods and guidelines should be designed for detection of antibiotic-resistant mechanisms.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 49 REFERENCES
Prevalence of Newer β-Lactamases in Gram-Negative Clinical Isolates Collected in the United States from 2001 to 2002
TLDR
Clinical laboratories must be able to detect important β-lactamases to ensure optimal patient care and infection control and avoid false susceptibility problems in laboratory testing problems of false susceptibility.
Extended broad-spectrum beta-lactamases conferring transferable resistance to newer beta-lactam agents in Enterobacteriaceae: hospital prevalence and susceptibility patterns.
TLDR
Before 1985 at the Pitié-Salpêtrière Hospital in Paris, resistance to cefotaxime in clinical isolates of Enterobacteriaceae involved only species producing inducible class 1 beta-lactamase; between November 1985 and April 1987, however, 62 isolates showed decreased susceptibility to cffotaximes, and these enzymes were designated EBS-Bla.
A Novel Complex Mutant β-Lactamase, TEM-68, Identified in a Klebsiella pneumoniae Isolate from an Outbreak of Extended-Spectrum β-Lactamase-Producing Klebsiellae
TLDR
TEM-68 was shown to be a novel complex mutant TEM β-lactamase (CMT-2) which combines strong ESBL activity with relatively weak IR activity and, when expressed in K. pneumoniae, is able to confer high-level resistance to a wide variety of β- lactams, including inhibitor combinations.
Prevalence and Molecular Epidemiology of CTX-M Extended-Spectrum β-Lactamase-Producing Escherichia coli and Klebsiella pneumoniae in Russian Hospitals
TLDR
This study provides further evidence of the global dissemination of CTX-M type ESBLs and emphasizes the need for their epidemiological monitoring.
Extended-Spectrum β-Lactamases in the 21st Century: Characterization, Epidemiology, and Detection of This Important Resistance Threat
  • P. Bradford
  • Biology, Medicine
    Clinical Microbiology Reviews
  • 2001
TLDR
β-Lactamases continue to be the leading cause of resistance to β-lactam antibiotics among gram-negative bacteria and are now found in a significant percentage of Escherichia coli and Klebsiella pneumoniae strains in certain countries.
Ambler Class A Extended-Spectrum Beta-Lactamase-Producing Escherichia coli and Klebsiella spp. in Canadian Hospitals
TLDR
Although a “clonal” distribution of isolates was observed at some individual sites, there was very little evidence suggesting intrahospital spread, and there was considerable diversity with respect to plasmid types observed.
Molecular Characterization of Extended-Spectrum Beta-Lactamases Produced by Clinical Isolates of Klebsiella pneumoniae and Escherichia coli from a Korean Nationwide Survey
TLDR
The prevalence and genotypes of extended-spectrum beta-lactamases (ESBLs) among clinical isolates of Klebsiella pneumoniae and Escherichia coli and one new variant identified for the first time in Korea were determined, namely, TEM-116.
Countrywide Spread of CTX-M-3 Extended-Spectrum β-Lactamase-Producing Microorganisms of the Family Enterobacteriaceae in Poland
TLDR
Analysis of clinical isolates of the family Enterobacteriaceae revealed a very high degree of diversity in β-lactam resistance levels and patterns, which was attributed to several factors, such as the production of other β- lactamases including additional ESBLs, possible quantitative variations in CTX-M-3 expression, segregation of AmpC derepressed mutants, and permeability alterations.
Nationwide Study of the Prevalence, Characteristics, and Molecular Epidemiology of Extended-Spectrum-β-Lactamase-Producing Enterobacteriaceae in France
TLDR
Molecular analysis underlined the polyclonal spread of CTX-M-expressing E. coli, primarily isolates of the CTX -M-1 subgroup.
Nationwide Study of Escherichia coli and Klebsiella pneumoniae Producing Extended-Spectrum β-Lactamases in Spain
ABSTRACT Clonal dissemination of extended-spectrum β-lactamases (ESBL) in 170 Escherichia coli isolates and 70 Klebsiella pneumoniae isolates from a nationwide study of 40 Spanish centers in 2000 was
...
1
2
3
4
5
...