Molecular Surveillance for Multidrug-Resistant Plasmodium falciparum, Cambodia


We conducted surveillance for multidrug-resistant Plasmodium falciparum in Cambodia during 2004-2006 by assessing molecular changes in pfmdr1. The high prevalence of isolates with multiple pfmdr1 copies found in western Cambodia near the Thai border, where artesunate-mefloquine therapy failures occur, contrasts with isolates from eastern Cambodia, where this combination therapy remains highly effective.

DOI: 10.3201/eid1410.080080

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@article{Shah2008MolecularSF, title={Molecular Surveillance for Multidrug-Resistant Plasmodium falciparum, Cambodia}, author={Naman Shah and Alisa P. Alker and Rithy Sem and Agustina Ika Susanti and Sinuon Muth and Jason D. Maguire and Socheat Duong and Fr{\'e}d{\'e}ric Ariey and Steven Richard Meshnick and Chansuda Wongsrichanalai}, journal={Emerging Infectious Diseases}, year={2008}, volume={14}, pages={1637 - 1640} }