Molecular Subgroup of Primary Prostate Cancer Presenting with Metastatic Biology.

  title={Molecular Subgroup of Primary Prostate Cancer Presenting with Metastatic Biology.},
  author={Steven M. Walker and Laura A. Knight and Andrena M McCavigan and Gemma E Logan and Viktor Berge and Amir Sherif and Hardev S. Pandha and Anne Y Warren and Catherine L. Davidson and Adam Uprichard and Jaine K. Blayney and Bethanie Price and Gera L. Jellema and Christopher M Steele and Aud Svindland and Simon McDade and Christopher G Eden and Chris Foster and Ian G Mills and David E. Neal and Malcolm David Mason and Elaine W. Kay and David J. J. Waugh and D. Paul Harkin and Ronald W Watson and Noel W. Clarke and Richard D. Kennedy},
  journal={European urology},
  volume={72 4},
BACKGROUND Approximately 4-25% of patients with early prostate cancer develop disease recurrence following radical prostatectomy. OBJECTIVE To identify a molecular subgroup of prostate cancers with metastatic potential at presentation resulting in a high risk of recurrence following radical prostatectomy. DESIGN, SETTING, AND PARTICIPANTS Unsupervised hierarchical clustering was performed using gene expression data from 70 primary resections, 31 metastatic lymph nodes, and 25 normal… CONTINUE READING