Molecular Structure of a Functional Drosophila Centromere

@article{Sun1997MolecularSO,
  title={Molecular Structure of a Functional Drosophila Centromere},
  author={X. Sun and J. Wahlstrom and G. Karpen},
  journal={Cell},
  year={1997},
  volume={91},
  pages={1007-1019}
}
Centromeres play a critical role in chromosome inheritance but are among the most difficult genomic components to analyze in multicellular eukaryotes. Here, we present a highly detailed molecular structure of a functional centromere in a multicellular organism. The centromere of the Drosophila minichromosome Dp1187 is contained within a 420 kb region of centric heterochromatin. We have used a new approach to characterize the detailed structure of this centromere and found that it is primarily… Expand
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