Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid

  title={Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid},
  author={James Dewey Watson and Francis H. C. Crick},
The determination in 1953 of the structure of deoxyribonucleic acid (DNA), with its two entwined helices and paired organic bases, was a tour de force in X-ray crystallography. But more significantly, it also opened the way for a deeper understanding of perhaps the most important biological process. In the words of Watson and Crick: "It has not escaped our notice that the specific pairing that we have postulated immediately suggests a possible copying mechanism for the genetic material… 
Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid
A structure for nucleic acid has already been proposed by Pauling and Corey and it is believed that the material which gives the X-ray diagrams is the salt, not the free acid, so without the acidic hydrogen atoms it is not clear what forces would hold the structure together.
Possible Simplified Structure of Deoxyribonucleic Acid
ALTHOUGH the Watson-Crick model1,2 provides a plausible explanation of the structure and replication of deoxyribonucleic acid, there remains one feature of it which, in our opionion, is unnecessarily
The complementary structure of deoxyribonucleic acid
  • F. CrickJ. Watson
  • Computer Science
    Proceedings of the Royal Society of London. Series A. Mathematical and Physical Sciences
  • 1954
This paper describes a possible structure for the paracrystalline form of the sodium salt of deoxyribonucleic acid. The structure consists of two DNA chains wound helically round a common axis, and
Superhelicity and Energetics of Structural Transitions of Nucleic Acids
The different helical structures are reviewed and the experimental methods to evaluate the energetics of structural transitions of nucleic acids are outlined.
DNA--structure and enzymatic synthesis.
Investigations of the interrelations among the 3 major biologic macromolecules, the so-called "holy trinity," — consisting of DNA, ribonucleic acid (RNA) and protein, have partially answered fundamental questions concerning gene structure, replication, and mutation.
Deoxyribonucleic acid structure: a new model.
Models of deoxyribonucleic acid (DNA) having chain directions opposite to those of the Watson and Crick model offer strikingly different alternatives for DNA structures. Satisfactory models of the B
Forces involved in the Conformational Stability of Nucleic Acids
This work shows that the presence, absence or modification of the 2′ hydroxyl group plays an important part in the conformational stability of the oligo and poly-nucleotides7–12.
Conformational principles of nucleic acids
The challenging task undertaken in nucleic acid structural studies is to elucidate the principles which underly the folding of polynucleotides, and ultimately to be able to predict structures.
Crystal structures of nucleic acids and their drug complexes.
The proposal for the structure of the DNA double helix in 1953 is generally considered to be the point at which genetic phenomena started to be understandable in molecular and chemical terms. Indeed
A structure for deoxyribose nucleic acid.
  • A. DeMaria
  • Chemistry
    Journal of the American College of Cardiology
  • 2003


Structure of the Nucleic Acids
WE have formulated a structure for the nucleic acids which is compatible with the main features of the X-ray diagram and with the general principles of molecular structure, and which accounts
  • G. R. Wyatt
  • Biology, Chemistry
    The Journal of general physiology
  • 1952
Purine and pyrimidine bases have been estimated from the desoxyribonucleic acids of eleven insect viruses, and no general parallelism is evident between DNA composition and biological relationship.