Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue

  title={Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue},
  author={J Lu and Wei Qiang and W M Yau and Charles D. Schwieters and S. C. Meredith and Robert Tycko},
In vitro, β-amyloid (Aβ) peptides form polymorphic fibrils, with molecular structures that depend on growth conditions, plus various oligomeric and protofibrillar aggregates. Here, we investigate structures of human brain-derived Aβ fibrils, using seeded fibril growth from brain extract and data from solid-state nuclear magnetic resonance and electron microscopy. Experiments on tissue from two Alzheimer's disease (AD) patients with distinct clinical histories showed a single predominant 40… CONTINUE READING
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