Molecular Single-Channel Behavior of Heteromeric 1 Glycine Receptors : An Attempt to Detect a Conformational Change before the Channel Opens

@inproceedings{Burzomato2004MolecularSB,
  title={Molecular Single-Channel Behavior of Heteromeric 1 Glycine Receptors : An Attempt to Detect a Conformational Change before the Channel Opens},
  author={Valeria Burzomato and Marco Beato and Paul J. Groot-Kormelink and David Colquhoun and Lucia G Sivilotti},
  year={2004}
}
The 1 heteromeric receptors are likely to be the predominant synaptic form of glycine receptors in the adult. Their activation mechanism was investigated by fitting putative mechanisms to single-channel recordings obtained at four glycine concentrations (10 –1000 M) from rat 1 receptors, expressed in human embryonic kidney 293 cells. The adequacy of each mechanism, with its fitted rate constants, was assessed by comparing experimental dwell time distributions, open-shut correlations, and the… CONTINUE READING

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