Molecular Signatures of Prostate Stem Cells Reveal Novel Signaling Pathways and Provide Insights into Prostate Cancer

@article{Blum2009MolecularSO,
  title={Molecular Signatures of Prostate Stem Cells Reveal Novel Signaling Pathways and Provide Insights into Prostate Cancer},
  author={Roy Blum and Rashmi Gupta and Patricia Burger and Christopher S. Ontiveros and Sarah N. Salm and Xiaozhong Xiong and Alexander Kamb and Holger Wesche and Lisa Marshall and Gene Cutler and Xiangyun Wang and Jiri Zavadil and David Moscatelli and Elaine Lynette Wilson},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={1257 - 1265}
}
BACKGROUND The global gene expression profiles of adult and fetal murine prostate stem cells were determined to define common and unique regulators whose misexpression might play a role in the development of prostate cancer. METHODOLOGY/PRINCIPAL FINDINGS A distinctive core of transcriptional regulators common to both fetal and adult primitive prostate cells was identified as well as molecules that are exclusive to each population. Elements common to fetal and adult prostate stem cells… CONTINUE READING

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