Molecular Signatures Distinguish Human Central Memory from Effector Memory CD8 T Cell Subsets1

@article{Willinger2005MolecularSD,
  title={Molecular Signatures Distinguish Human Central Memory from Effector Memory CD8 T Cell Subsets1},
  author={T. Willinger and T. Freeman and H. Hasegawa and A. McMichael and M. Callan},
  journal={The Journal of Immunology},
  year={2005},
  volume={175},
  pages={5895 - 5903}
}
Memory T cells are heterogeneous in terms of their phenotype and functional properties. We investigated the molecular profiles of human CD8 naive central memory (TCM), effector memory (TEM), and effector memory RA (TEMRA) T cells using gene expression microarrays and phospho-protein-specific intracellular flow cytometry. We demonstrate that TCM have a gene expression and cytokine signaling signature that lies between that of naive and TEM or TEMRA cells, whereas TEM and TEMRA are closely… Expand
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