Molecular Signalling, Pharmacology, and Physiology of Octopamine and Tyramine Receptors as Potential Insect Pest Control Targets

@article{Ohta2014MolecularSP,
  title={Molecular Signalling, Pharmacology, and Physiology of Octopamine and Tyramine Receptors as Potential Insect Pest Control Targets},
  author={Hiroto Ohta and Yoshihisa Ozoe},
  journal={Advances in Insect Physiology},
  year={2014},
  volume={46},
  pages={73-166}
}
The Insect Type 1 Tyramine Receptors: From Structure to Behavior
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This review summarizes the available information on TAR1 from different insect species in terms of basic structure, its regulation and signal transduction mechanisms, and its distribution and functions in the brain and the periphery as well as future directions on which the receptor research should move.
AmOctα2R: Functional Characterization of a Honeybee Octopamine Receptor Inhibiting Adenylyl Cyclase Activity
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The functional characterization of AmOctα2R adds a sixth member to this subfamily of monoaminergic receptors in the honeybee and is an important step towards understanding the actions of octopamine in honeybee behavior and physiology.
Pharmacological Properties of the Type 1 Tyramine Receptor in the Diamondback Moth, Plutella xylostella
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The temporal and spatial differences and pharmacological properties of Pxtar1 in P. xylostella are revealed and a strategy for screening insecticidal compounds that target PxTAR1 is provided.
Pharmacological characterization of a β-adrenergic-like octopamine receptor in Plutella xylostella.
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It was found that PxOA2B2 could be activated by both octopamine and tyramine, resulting in increased intracellular cyclic AMP levels, whereas dopamine and serotonin were not effective in eliciting cAMP production.
Ion channels and G protein-coupled receptors as targets for invertebrate pest control: from past challenges to practical insecticides.
  • Y. Ozoe
  • Biology
    Bioscience, biotechnology, and biochemistry
  • 2021
TLDR
Of the tested receptors, β-adrenergic-like octopamine receptors were revealed to be the most sensitive to the acaricide/insecticide amitraz, and ion channels and GPCRs remain potential targets for invertebrate pest control.
PaOctβ2R: Identification and Functional Characterization of an Octopamine Receptor Activating Adenylyl Cyclase Activity in the American Cockroach Periplaneta americana
TLDR
The functional characterization of PaOctβ2R and the bioinformatics data uncovered that the monoaminergic receptor family in the hemimetabolic P. americana is similarly complex as in holometabolic model insects like Drosophila melanogaster and the honeybee, Apis mellifera.
Monoterpenes alter TAR1-driven physiology in Drosophila species
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It appears that monoterpenes not only act as biopesticides for Drosophila but also can interfere with Drosophile behaviour and metabolism in a TAR1-dependent fashion.
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