Molecular Setting the Time Course of Inhibitory Synaptic Currents by Mixing Multiple GABAA Receptor Subunit Isoforms

The kinetics of IPSCs influence many neuronal processes, such as the frequencies of oscillations and the duration of shunting inhibition. The subunit composition of recombinant GABAA receptors (GABAARs) strongly affects the deactivation kinetics of GABA-evoked currents. However, for GABAergic synapses, the relationship between subunit composition and IPSC… CONTINUE READING