Molecular Regulation of the Neuronal Proteasome by Zif 268 ( Egr 1 )

@inproceedings{James2006MolecularRO,
  title={Molecular Regulation of the Neuronal Proteasome by Zif 268 ( Egr 1 )},
  author={Allan B James and A Conway and Brian J. Morris},
  year={2006}
}
Most forms of neuronal plasticity are associated with induction of the transcription factor Zif268 (Egr1/Krox24/NGF-IA). In a genomewide scan, we obtained evidence for potential modulation of proteasome subunit and regulatory genes by Zif268 in neurons, a finding of significance considering emerging evidence that the proteasome modulates synaptic function. Bioinformatic analysis indicated that the candidate proteasome Zif268 target genes had a rich concentration of putative Zif268 binding sites… CONTINUE READING