Molecular Regulation of Parturition: A Myometrial Perspective.

  title={Molecular Regulation of Parturition: A Myometrial Perspective.},
  author={Nora E. Renthal and Koriand'r C. Williams and Alina P Montalbano and Chien-Cheng Chen and Lu Gao and Carole R. Mendelson},
  journal={Cold Spring Harbor perspectives in medicine},
  volume={5 11}
The molecular mechanisms that maintain quiescence of the myometrium throughout most of pregnancy and promote its transformation to a highly coordinated contractile unit culminating in labor are complex and intertwined. During pregnancy, progesterone (P4) produced by the placenta and/or ovary serves a dominant role in maintaining myometrial quiescence by blocking proinflammatory response pathways and expression of so-called "contractile" genes. In the majority of placental mammals, increased… CONTINUE READING
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