Molecular Regulation of NaV 1 . 2 Channels by Brain-Derived Neurotrophic Factor , TrkB , and Associated Fyn Kinase

Abstract

Voltage-gated sodium channels are responsible for action potential initiation and propagation in neurons, and modulation of their function has an important impact on neuronal excitability. Sodium channels are regulated by a Src-family tyrosine kinase pathway, and this modulation can be reversed by specifically bound receptor phosphoprotein tyrosine… (More)

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