Molecular Regulation of Na+-K+-2C1- Cotransporter (NKCC1) and Epithelial Chloride Secretion

@article{Matthews2002MolecularRO,
  title={Molecular Regulation of Na+-K+-2C1- Cotransporter (NKCC1) and Epithelial Chloride Secretion},
  author={Jeffrey B. Matthews},
  journal={World Journal of Surgery},
  year={2002},
  volume={26},
  pages={826-830}
}
Defective regulation of epithelial secretion underlies the clinical manifestations of a number of important human diseases ranging from cystic fibrosis to secretory diarrhea. Although much attention has focused on the role of apical membrane chloride (Cl-) channels in this process, emerging evidence highlights the importance of a basolateral Na+-K+-2Cl- cotransporter (NKCC1) as an independent regulatory site that may determine the overall rate of epithelial secretion. The cotransporter NKCC1 is… CONTINUE READING

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