Molecular Reconstruction of Sleeping Beauty, a Tc1-like Transposon from Fish, and Its Transposition in Human Cells

@article{Ivics1997MolecularRO,
  title={Molecular Reconstruction of Sleeping Beauty, a Tc1-like Transposon from Fish, and Its Transposition in Human Cells},
  author={Z. Ivics and P. Hackett and R. Plasterk and Z. Izsv{\'a}k},
  journal={Cell},
  year={1997},
  volume={91},
  pages={501-510}
}
  • Z. Ivics, P. Hackett, +1 author Z. Izsvák
  • Published 1997
  • Biology, Medicine
  • Cell
  • Members of the Tc1/mariner superfamily of transposons isolated from fish appear to be transpositionally inactive due to the accumulation of mutations. Molecular phylogenetic data were used to construct a synthetic transposon, Sleeping Beauty, which could be identical or equivalent to an ancient element that dispersed in fish genomes in part by horizontal transmission between species. A consensus sequence of a transposase gene of the salmonid subfamily of elements was engineered by eliminating… CONTINUE READING

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