Molecular Properties of Sodium/Dicarboxylate Cotransporters

@article{Pajor2000MolecularPO,
  title={Molecular Properties of Sodium/Dicarboxylate Cotransporters},
  author={Ana M. Pajor},
  journal={The Journal of Membrane Biology},
  year={2000},
  volume={175},
  pages={1-8}
}
  • A. Pajor
  • Published 1 May 2000
  • Biology
  • The Journal of Membrane Biology
The active transport of Krebs cycle intermediates, such as succinate, a-ketoglutarate and citrate, is mediated by sodium-coupled transporters found on the plasma membranes of many epithelial cells. The preferred substrates of these transporters are dicarboxylates. Tricarboxylate substrates, such as citrate, are carried in protonated form. At least two classes of Na /dicarboxylate cotransporters have been identified, distinguished by differences in their relative affinity for succinate. The low… 
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