Molecular Profiling of Neurons Based on Connectivity

@article{Ekstrand2014MolecularPO,
  title={Molecular Profiling of Neurons Based on Connectivity},
  author={Mats I. Ekstrand and Alexander R. Nectow and Zachary A Knight and Kaamashri N. Latcha and Lisa E. Pomeranz and Jeffrey M. Friedman},
  journal={Cell},
  year={2014},
  volume={157},
  pages={1230-1242}
}
The complexity and cellular heterogeneity of neural circuitry presents a major challenge to understanding the role of discrete neural populations in controlling behavior. While neuroanatomical methods enable high-resolution mapping of neural circuitry, these approaches do not allow systematic molecular profiling of neurons based on their connectivity. Here, we report the development of an approach for molecularly profiling projective neurons. We show that ribosomes can be tagged with a camelid… CONTINUE READING
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