Molecular Prodigality

@article{Bray2003MolecularP,
  title={Molecular Prodigality},
  author={D. Bray},
  journal={Science},
  year={2003},
  volume={299},
  pages={1189 - 1190}
}
  • D. Bray
  • Published 21 February 2003
  • Biology
  • Science
G enome studies reveal that we share about 95% of our DNA sequence with chimpanzees (1). This confirms something we have known for years: We are not solely the products of our genes, but of our genes interacting with each other and with the environment. The outcome is a prodigiously complicated chemical system that not only renders humans different from monkeys, but also makes each human being (and probably each cell of each human being) unique. In living cells, macromolecules, and especially… 

After the genome—the phenome?

  • C. Scriver
  • Biology
    Journal of Inherited Metabolic Disease
  • 2004
TLDR
Clinician-scientists will be recognized as key participants in the ‘medical’ Phenome Project as it reveals components of individuality, and their contributions to Mendelian and complex traits; better ways to treat ‘genetic disease’ will be by-products of the project.

Combinatorial complexity and dynamical restriction of network flows in signal transduction.

TLDR
The relative importance of molecular species that can be generated during signalling, chemical transitions among these species, and reaction paths that lead to activation of the protein tyrosine kinase (PTK) Syk.RI is determined.

Adaptational assistance in clusters of bacterial chemoreceptors

TLDR
Observations indicate that chemoreceptors can form stable neighbourhoods larger than trimers in the absence of other chemotaxis proteins, likely to occur in natural receptor clusters in vivo.

The complexity of complexes in signal transduction

TLDR
The role of multicomponent complexes in signal transduction is reviewed and the use of mathematical models that incorporate detail at the level of molecular domains to study this important aspect of cellular signaling is advocated.

Rules for Modeling Signal-Transduction Systems

TLDR
Approaches to creation of mathematical models of signaling systems with strategies that keep the models from being unwieldy but still allow them to accurately reflect biological systems are reviewed.

Graphical rule-based representation of signal-transduction networks

TLDR
Concepts for representing signal-transduction networks that are both comprehensible and precise are developed.

Making sense of it all: bacterial chemotaxis

TLDR
The increasing number of sequenced bacterial genomes shows that although the central sensory mechanism seems to be common to all bacteria, there is added complexity in a wide range of species.

Depicting signaling cascades

TLDR
An alternative method of representation is called attention to that better addresses the problem of combinatorial complexity in signal-transduction cascades, which involves the use of graphical reaction rules to represent the protein-protein interactions in a system and their consequences.

References

SHOWING 1-10 OF 16 REFERENCES

Neurexins: three genes and 1001 products.

Modulation of the Thermosensing Profile of the Escherichia coli Aspartate Receptor Tar by Covalent Modification of Its Methyl-accepting Sites*

TLDR
It is suggested that Tar exists in at least three distinct states, each of which allows it to function as a warm, cold, or null thermoreceptor, depending on the modification patterns of its methylation sites.

Collaborative signaling by mixed chemoreceptor teams in Escherichia coli

TLDR
Interactions between serine (Tsr) and aspartate (Tar) chemoreceptors in Escherichia coli are investigated by constructing Tsr mutations at the six hydrophobic and five polar residues implicated in “trimer of dimers” formation, indicating that bacterial chemoreceptor clusters are comprised of signaling teams that can contain different receptor types acting collaboratively.

Hsp90 as a capacitor of phenotypic variation

TLDR
It is reported that, in Arabidopsis accessions and recombinant inbred lines, reducing Hsp90 function produces an array of morphological phenotypes, which are dependent on underlying genetic variation, and that HSp90 influences morphogenetic responses to environmental cues and buffers normal development from destabilizing effects of stochastic processes.

Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing.

TLDR
It is shown that Drosophila melanogaster and Caenorhabditis elegans express a single gene encoding only an alpha-neurexin, whereas humans and mice express three genes, each of which encodes alpha- and beta-neurxins transcribed from separate promoters.

A new kind of science

TLDR
A New Kind of Science, written and published by Stephen Wolfram, is the outcome of the studies he conducted systematically upon cellular automata, a class of computer model which may be visualized as a set of memory locations, each containing one bit.

Expression of multiple troponin T isoforms in chicken breast muscle regeneration induced by sub-serous implantation.

TLDR
The immunohistochemical results suggested that the regulation of alternative splicing of F-type TnT pre-mRNAs was different among individual myofibers, and that theregulation was programmed in myogenic cells, probably satellite cells, which were the primary source of the fibers.

Creatine kinase B‐driven energy transfer in the brain is important for habituation and spatial learning behaviour, mossy fibre field size and determination of seizure susceptibility

TLDR
A role is indicated for the creatine–phosphocreatine/CK circuit in the formation or maintenance of hippocampal mossy fibre connections, and processes that involve habituation, spatial learning and seizure susceptibility, but for fuelling of basic physiological activities the role of B‐CK can be compensated for by other systems in the versatile and robust metabolic‐energy network of the brain.

Differentiation

The Evolution of DifferentiationBy William S. Bullough. Pp. vi + 206. (London and New York: Academic Press, 1967.) 45s; $8.