Molecular Physiology of Mammalian Glucokinase

  title={Molecular Physiology of Mammalian Glucokinase},
  author={Patrick B. Iynedjian},
  journal={Cellular and Molecular Life Sciences },
  pages={27 - 42}
The glucokinase (GCK) gene was one of the first candidate genes to be identified as a human “diabetes gene". Subsequently, important advances were made in understanding the impact of GCK in the regulation of glucose metabolism. Structure elucidation by crystallography provided insight into the kinetic properties of GCK. Protein interaction partners of GCK were discovered. Gene expression studies revealed new facets of the tissue distribution of GCK, including in the brain, and its regulation by… CONTINUE READING
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Diabetes models by screen for hyperglycemia in phenotypedrivenENUmousemutagenesis projects

  • B. Aigner, B. Rathkolb, N. Herbach, M. Hrabe de Angelis
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