Molecular Pathways Associated with Stress Resilience and Drug Resistance in the Chronic Mild Stress Rat Model of Depression—a Gene Expression Study

@article{Bergstrm2007MolecularPA,
  title={Molecular Pathways Associated with Stress Resilience and Drug Resistance in the Chronic Mild Stress Rat Model of Depression—a Gene Expression Study},
  author={A. Bergstr{\"o}m and Magdalena Niepsuj Jayatissa and Thomas Thykj{\ae}r and Ove Wiborg},
  journal={Journal of Molecular Neuroscience},
  year={2007},
  volume={33},
  pages={201-215}
}
The current antidepressant drugs are ineffective in 30 to 40% of the treated patients; hence, the pathophysiology of the disease needs to be further elucidated. We used the chronic mild stress (CMS) paradigm to induce anhedonia, a core symptom of major depression, in rats. A fraction of the animals exposed to CMS is resistant to the development of anhedonia; they are CMS resilient. In the CMS-sensitive animals, the induced anhedonic state is reversed in 50% of the animals when treating with… CONTINUE READING