Molecular Pathology of Severe Combined Immunodeficiency in Mice, Horses, and Dogs

@article{Perryman2004MolecularPO,
  title={Molecular Pathology of Severe Combined Immunodeficiency in Mice, Horses, and Dogs},
  author={Lance E. Perryman},
  journal={Veterinary Pathology},
  year={2004},
  volume={41},
  pages={100 - 95}
}
  • L. Perryman
  • Published 1 March 2004
  • Biology
  • Veterinary Pathology
Severe combined immunodeficiency (SCID) is an inherited disorder of humans, mice, horses, and dogs, in which affected individuals are incapable of generating antigen-specific immune responses. It occurs when lymphocyte precursors fail to differentiate into mature lymphocytes because of mutations within recombinase-activating genes 1 and 2 or within the genes encoding deoxyribonucleic acid (DNA)-dependent protein kinase (DNA-PK). It also occurs when differentiated lymphocytes are incapable of… 
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References

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TLDR
It is shown that the factor defective in the autosomal recessive severe combined immunodeficiency of Arabian foals is required for (i) V(D)J recombination, (ii) resistance to ionizing radiation, and (iii) DNA-dependent protein kinase activity.
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TLDR
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