Molecular Pathology of Severe Combined Immunodeficiency in Mice, Horses, and Dogs

@article{Perryman2004MolecularPO,
  title={Molecular Pathology of Severe Combined Immunodeficiency in Mice, Horses, and Dogs},
  author={Lance E. Perryman},
  journal={Veterinary Pathology},
  year={2004},
  volume={41},
  pages={100 - 95}
}
  • L. Perryman
  • Published 1 March 2004
  • Biology
  • Veterinary Pathology
Severe combined immunodeficiency (SCID) is an inherited disorder of humans, mice, horses, and dogs, in which affected individuals are incapable of generating antigen-specific immune responses. It occurs when lymphocyte precursors fail to differentiate into mature lymphocytes because of mutations within recombinase-activating genes 1 and 2 or within the genes encoding deoxyribonucleic acid (DNA)-dependent protein kinase (DNA-PK). It also occurs when differentiated lymphocytes are incapable of… 

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