Molecular Origins of Cancer Epigenetics in Cancer

  title={Molecular Origins of Cancer Epigenetics in Cancer},
  author={Manel Esteller},
Copyright © 2008 Massachusetts Medical Society. Classic genetics alone cannot explain the diversity of phenotypes within a population. Nor does classic genetics explain how, despite their identical DNA sequences, monozygotic twins1 or cloned animals2 can have different phenotypes and different susceptibilities to a disease. The concept of epigenetics offers a partial explanation of these phenomena. First introduced by C.H. Waddington in 1939 to name “the causal interactions between genes and… CONTINUE READING
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