Molecular Organization of Drosophila Neuroendocrine Cells by Dimmed

  title={Molecular Organization of Drosophila Neuroendocrine Cells by Dimmed},
  author={Dongkook Park and Tarik Hadzic and Ping Yin and Jannette Rusch and Katharine C Abruzzi and Michael Rosbash and James B Skeath and Satchidananda Panda and Jonathan V. Sweedler and Paul H Taghert},
  journal={Current Biology},
BACKGROUND In Drosophila, the basic-helix-loop-helix protein DIMM coordinates the molecular and cellular properties of all major neuroendocrine cells, irrespective of the secretory peptides they produce. When expressed by nonneuroendocrine neurons, DIMM confers the major properties of the regulated secretory pathway and converts such cells away from fast neurotransmission and toward a neuroendocrine state. RESULTS We first identified 134 transcripts upregulated by DIMM in embryos and then… CONTINUE READING
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