Molecular Nevogenesis

  title={Molecular Nevogenesis},
  author={Andrew L. Ross and Margaret I. Sanchez and James M. Grichnik},
  booktitle={Dermatology research and practice},
Despite recent advances, the biology underlying nevogenesis remains unclear. Activating mutations in NRAS, HRAS, BRAF, and GNAQ have been identified in benign nevi. Their presence roughly correlates with congenital, Spitz, acquired, and blue nevi, respectively. These mutations are likely to play a critical role in driving nevogenesis. While each mutation is able to activate the MAP kinase pathway, they also interact with a host of different proteins in other pathways. The different melanocytic… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 22 extracted citations


Publications referenced by this paper.
Showing 1-10 of 59 references

High BRAF mutation frequency does not characterize all melanocytic tumor types.

International journal of cancer • 2004
View 7 Excerpts
Highly Influenced

Mutations of the BRAF gene in benign and malignant melanocytic lesions.

The Journal of investigative dermatology • 2003
View 4 Excerpts
Highly Influenced

BRAF and NRAS mutations in melanoma and melanocytic nevi.

Melanoma research • 2006
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…