Molecular Neuropathology of TDP-43 Proteinopathies

@article{Neumann2009MolecularNO,
  title={Molecular Neuropathology of TDP-43 Proteinopathies},
  author={Manuela Neumann},
  journal={International Journal of Molecular Sciences},
  year={2009},
  volume={10},
  pages={232 - 246}
}
The identification of TDP-43 as the major component of the pathologic inclusions in most forms of sporadic and familial frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) and amyotrophic lateral sclerosis (ALS) resolved a long-standing enigma concerning the nature of the ubiquitinated disease protein under these conditions. Anti-TDP-43 immunohistochemistry and the recent development of novel tools, such as phosphorylation-specific TDP-43 antibodies, have increased our… CONTINUE READING

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